Indeed, bone and cartilage development pathways were enriched in signals traversing weight bearing and non-weight bearing joints, identifying joint development as a common mechanism for any form of osteoarthritis (Table S13). KLADKOSTROJ BRANO Mal velk pneumatick pomocnk, Novinka od Brana Litov koordintor dve Brano K610, Zednick kladka BRANO a kladka obecn uiten pomocnk, kter nm slou ji mnoho stolet. The ARGO collection was conducted in three public hospitals (Attikon University General Hospital of Athens, Nea Ionia General Hospital Konstantopouleio, and KAT Hospital) and one private hospital (Lefkos Stavros General Hospital) in the city of Athens, Greece between February of 2015 and March 2017. Graphical summary of the Genetics of Osteoarthritis Consortium workflow and results. Bilateral multiple lobular and subsegmental areas of consolidation are typical findings on chest CT-scan of ICU-admitted patients [7]. Ensembl resource was used to obtain genes and variants annotation. We have now placed Twitpic in an archived state. Notably, we identified another new THR and hand osteoarthritis-associated signal located in such a transcription factor, the TEAD1 gene, indicating a common molecular pathway underlying both signals (Figure3B). Cell 173:1573-1580. Chan J.F.-W., Yuan S., Kok K.-H., To K.K.-W., Chu H., Yang J. En ce qui concerne l'homologie des nuclotides, le SARS-CoV-2 est 79,5% identique celui du SARS-CoV[14] et 50% identique celui du MERS-CoV[15]. En revanche, IFITM(en), (interferon-inducible transmembrane protein), une protine transmembranaire produite en prsence d'interfrons, peut bloquer cette fusion. To glean further insight into the biological role of the high-confidence effector genes in disease processes, we integrated additional information based on the analysis of endophenotypes more closely related to the underlying biology, monogenic and rare human disease data, phenome-wide analyses, and additional functional genomics data (Tables S11 and S12; STAR Methods). Biospecimen Collection Source Site-RPCI. co-factor in collagen synthesis, carbohydrate, and lipid metabolism; antioxidant. Aussi, en 2015, Bruno Canard dnonce le dsengagement europen et franais dans le secteur des sciences et adresse avec ses collgues belges et hollandais, des lettres dintention la Commission europenne expliquant quil existe neuf familles de virus pour lesquelles une mergence est possible. (F) Venn diagram depicting the number and overlap of SNVs associated with weight bearing and non-weight bearing joints. The cases had been reported since December 8, 2019, and many patients worked at or lived around the local Huanan Seafood Wholesale Market although other early cases had no exposure to this market [1]. (G) Circos plot depicting the overlap in osteoarthritis associations of the 100 lead variants. Wray NR, Wijmenga C, Sullivan PF, Yang J, Visscher PM (2018), Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AAE, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H, et al. Abbreviations: osteoarthritis (OA) phenotype, OA phenotype with a genome-wide significant association (p< 1.3 108) with the exception of the early-onset analysis (p< 5 108); other osteoarthritis phenotypes, other OA phenotypes associated with this SNV at GWS level but less significant than OA phenotype; AllOA, OA at any joint site; KneeOA, OA of the knee; HipOA, OA of the hip; KneeHipOA, KneeOA and/or HipOA; TJR, total knee and/or hip replacement; TKR, total knee replacement; THR, total hip replacement; SpineOA, OA of the spine; FingerOA, OA of the finger; ThumbOA, OA of the thumb; HandOA, FingerOA and/or ThumbOA; EA, effect allele; NEA, Non-Effect allele; EAF, effect allele frequency; OR, odds ratio; 95% CI, 95% confidence interval of the OR; Annotation, most severe consequence according to grch37 Ensembl REST API (Yates etal., 2015), if missense the amino acid change is provided according to the Human Gene Mutation Database nomenclature; NearestGene, nearest gene according to grch37 Ensembl REST API; WtGrp, which weight bearing group the signal belongs to (p< 5 104), 0= weight bearing only, 1= weight bearing and non-weight bearing, 2= non-weight bearing only, NA= unclassified due to incomplete information for all phenotypes, a female specific association or an AllOA association. Biopsy Jpg ; 500x427 px ; 22.7 KB ; Print download Onedrive Icon File nice staff and members! Yengo L, Zhu ZH, Wray NR, Weir BS, Yang J, Robinson MR, Visscher PM (2018), Estimation of inbreeding depression from SNP data REPLY. Bulik-Sullivan B.K., Loh P.R., Finucane H.K., Ripke S., Yang J., Patterson N., Daly M.J., Price A.L., Neale B.M., Schizophrenia Working Group of the Psychiatric Genomics Consortium LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Ces protines sassemblent entre elles dans le lumen (lintrieur) dun compartiment driv du rticulum endoplasmique[81]. Wang Y, Guo J, Ni GY, Yang J, Visscher PM, Yengo L (2020), Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations. Mechanoadaptation: articular cartilage through thick and thin. Sumita J.M., Leonardi G.R., Bagatin E. Tretinoin peel: a critical view. Trois principales sources sont utilises: l'Institut Pasteur, l'OMS et les CDC amricains[37]. For the eQTL colocalization using GTEx tissues, we considered the following GTEx tissues as possible osteoarthritis target tissues, based on the tissue specificity analysis: Adipose, Brain, Heart, Lung, Muscle, Nerve, Ovary, Placenta, Skin, Stomach, Cultured fibroblasts, Adrenal gland, and Breast tissue. Nine protein-osteoarthritis associations showed reliable MR and colocalization evidence (Bonferroni corrected, p< 2.77x106 and colocalization probability > 70%) for a total of six proteins on seven osteoarthritis phenotypes (Table S7). American Journal of Human Genetics 97:75-85. Meta-analysis of sex-specific genome-wide association studies. C Children's emotional understanding. Suhre K., Arnold M., Bhagwat A.M., Cotton R.J., Engelke R., Raffler J., Sarwath H., Thareja G., Wahl A., DeLisle R.K. To investigate if any of the high-confidence effector genes show a different expression in osteophytes, indicating a potential role inrepair mechanisms in response to joint cartilage degeneration, we investigated if they showed significant (0.1% FDR) differential gene expression, methylation or differential protein abundance in osteophytic cartilage compared to low-grade (intact) cartilage in a within-individual matched analysis from 9 individuals who had undergone THR for primary osteoarthritis (Steinberg etal., 2018) (Table S12). Using FUSION [26], which generates the linear sum of Z score weights for the independent SNPs at the locus, then the genetic influence of lacunar stroke (lacunar stroke GWAS Z score) was combined with the mRNA expression weights. Octavia E. Butler First, pQTL and eQTL mapping cannot solve all GWAS signals. (2015), Mendelian randomization study of height and risk of colorectal cancer. We thank Dr.Wingo (Division of Mental Health, Atlanta VA Medical Center, Decatur, GA, USA) for making the human brain weights public available. The initial number of pregnancies enrolled is 14,541 (for these at least one questionnaire has been returned or a Children in Focus clinic had been attended by 19/07/99). We combined the lacunar stroke GWAS data with human brain transcriptomes to conduct a lacunar stroke transcriptome-wide association analysis (TWAS) using FUSION. The current COVID-19 pandemic is clearly an international public health problem. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden les SARS-CoV-2 et SARS-CoV-1 ont en commun les protines 3a, 6, 7a, 7b, 9b et 9c; les protines 3b et 8 du SARS-CoV-2 sont diffrentes des protines 3b, 8a et 8b du SARS-CoV-1. We used conditional analyses to identify associations that do not overlap across disease phenotype definitions. Annual Review of Genetics 47:75-95. Le SARS-CoV-2 est une nouvelle souche de coronavirus SARSr-CoV. Protein weights from the most predictive model were selected. Sun XW, Yang J (2021), Towards the understanding of the genetics of somatic mutations. Discord Logo Png Black. On January 18, 2020 the epidemiological criterion was expanded to include contact with anyone who had been in Wuhan in the past 2 weeks [50]. Selon Mediapart, la France n'aurait publi que 394gnomes dans cette base, soit peine 1% du nombre total de gnomes partags au niveau international[195]. Zaharija B., Samardija B., Bradshaw N.J. Pour le coronavirus dcouvert en 2019, voir SARS-CoV-2. Regenhardt RW, Das AS, Lo EH, Caplan LR. Remdesivir which was developed for Ebola virus, has been used to treat imported COVID-19 cases in US [61]. Samples that passed quality control were analyzed in a second round of genotype calling following the Genome Studio quality control protocol described elsewhere (Guo etal., 2014). We used the default COLOC priors of p1 = 104, p2 = 104, and p12 = 105, where p1 is the probability that a given variant is associated with lacunar stroke, p2 is the probability that a given variant is a significant pQTL, and p12 is the probability that a given variant is both a lacunar stroke result and an pQTL. Nature Communications 6:5890. (2020), A unified framework for association and prediction from vertex-wise grey-matter structure. Five rare diseases Cohort-level summary statistics and raw data for HUNT are available upon application. Neurobiology of Aging 74:234.e9-234.e15. (2015), The UK10K project identifies rare variants in health and disease. Linner RK, Biroli P, Kong E, Meddens FW, Wedow R, Fontana MA, Lebreton M, Tino SP, et al. Who Is Brenda Woodard? New Details About Parkland Shooter DECIPHER database resource was used to identify if any of the high confidence effector genes are implicated in monogenic and rare human diseases. Fewer COVID-19 cases have been reported in children less than 15 years [20], [30], [7], [32]. Identification of these genes can also have implications for further joint pain-related disorders, for which insights have been limited to date. Cohort-level summary statistics For GARP study and LLS are available upon request. Genomic variation. We generated PRS in the genome-wide meta-analysis excluding the deCODE dataset and used univariate linear regression to test the predictiveness of the scores on age at joint replacement in the deCODE cohort (Table S4). auf dass haben sie das absolute sowie dank der Le MHV pntre le Systme nerveux central (SNC) via les neurones du nerf olfactif, et peut causer une encphalite aigu ou une maladie dmylinisante chronique s'il y persiste (il peut aussi se propager jusqu la moelle pinire)[19],[21]. Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept. Among those countries, 11 countries have reported local transmission with the highest number of cases reported in Singapore with 47 confirmed cases [6]. First, while the exact link between eQTLs and pQTLs has yet to be discovered, the mRNA expression and protein levels of many genes are uncorrelated, owing in part to various posttranscriptional factors such as sequence characteristics implicated in protein translation and degradation [63]. Le gnome du SARS-CoV-2 est constitu d'un ARN simple-brin de 29903nuclotides[11],[12],[13]. Nikolas Cruz sentencing latest: Prosecution rests rebuttal case Human Reproduction 35:377-393. Jin Y.H., Cai L., Cheng Z.S., Cheng H., Deng T., Fan Y.P. (2019), Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. D'abord l'ARN positif du virus est transcrit en protine pour former une. We demonstrate genetic correlation between osteoarthritis and pain-related phenotypes and identify signal enrichment in neurological pathways (Table S13). - Dark blue Rainbow Neon - iOS 14 70+ Icon Pack these Png clip art. Art, discord Integration 1.2.1 | NixFifty Services image for free of 5 +4K +5K ; Tags discord! Wray NR, Yang J, Hayes BJ, Price AL, Goddard ME, Visscher PM (2013), Pitfalls of predicting complex traits from SNPs. T.R.G. 1Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan China, 2Department of Neurology, the 3rd Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan China, 3Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu China, 4Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh Peoples Hospital, Zhejiang University School of Medicine, Hangzhou Zhejiang, China, 5NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Zhejiang, Hangzhou China. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. PA, Heath AC, et al. Nous les avons donc tudis tous en mme temps, afin den avoir un modle type qui nous permettrait, en cas de menace dun virus inconnu, den trouver un proche, do nous pourrions extraire des donnes scientifiques[22]. Available upon application to kontakt@hunt.ntnu.no. R Index variants were classified as known if they have previously been reported or the association signal disappeared after conditioning on the variant of a previously reported locus. Differentially expressed genes were defined at 2 fold-change with Benjamini-Hochberg corrected p 0.05 (Table S9). The quality control (QC) was performed centrally by using EasyQC (Winkler etal., 2014). Fang Li, Wenhui Li, Michael Farzan et Stephen C. Harrison, Cascella M, Rajnik M, Cuomo A, et al. Data was collected through three cross-sectional surveys, HUNT1 (1984-1986), HUNT2 (1995-1997) and HUNT3 (2006-2008), and has been described in detail previously (Krokstad etal., 2013), with the fourth survey recently completed (HUNT4, 2017-2019). we have really nice staff and chill members, daily gifs & icons etc. White Flat Taskbar Icons, qBittorrent, white and blue qb logo transparent background PNG clipart size: 256x256px filesize: 5.33KB. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. China C.D.C. developed a novel framework called proteome-wide association studies (PWAS) to combine gene and protein expression data with the results of GWAS (integrate gene expression data and GWAS results) in depression pathogenesis [12]. Eating Disorders Working Group of the Psychiatric Genomics Consortium. Free Icons Library. ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome. American Journal of Human Genetics 88:76-82. Wan Y., Shang J., Graham R., Baric R.S., Li F. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. Chou C.H., Wu C.C., Song I.W., Chuang H.P., Lu L.S., Chang J.H., Kuo S.Y., Lee C.H., Wu J.Y., Chen Y.T. Khler S., Gargano M., Matentzoglu N., Carmody L.C., Lewis-Smith D., Vasilevsky N.A., Danis D., Balagura G., Baynam G., Brower A.M. (2019), Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Osteoarthritis was defined by either a) self-reported osteoarthritis, b) clinical diagnosed, c) ICD10 codes (Table S1) or d) radiographic as defined by the TREAT-OA consortium (Kerkhof etal., 2011), depending on the data available in the cohort (Table S1). In addition, we identify two independent genetic variants implicating noggin (NOG) as an osteoarthritis effector gene. To summarize the significance of the signals that have supportive evidence in East Asian ancestry-only meta-analysis, we conducted a binomial test (N= 10 SNVs with concordant direction and p 0.05, N= 77 SNVs tested, and 0.025 is the expected proportion of SNVs at p 0.05 and with the same direction of effect). Verweij KJH, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Raback L, Heinonen K, Pouta A, et al. Discord Logo Black And White. Nature Communications 6:8570. The Nord-Trndelag Health Study (HUNT) is a large population-based cohort from the county Nord-Trndelag in Norway. (2020), Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Pinterest. The variant is nominally significantly associated in all contributing studies and with the same direction of effect. Diagnostic tests, such as amniocentesis and chorionic villus sampling, do much better (about 99% accuracy) but These findings are supported by animal model data, in which inactivation of SOX5 leads to defects in skeletogenesis such as in cartilage development, the notochord, and intervertebral discs in mice (Smits and Lefebvre, 2003; Smits etal., 2001). Song Y.Q., Karasugi T., Cheung K.M., Chiba K., Ho D.W., Miyake A., Kao P.Y., Sze K.L., Yee A., Takahashi A. Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant. The significance for enrichment was set to genome-wide significance (p< 1.3x108) (FigureS1). Nature Communications 8:611. is a consultant for Zoe Global Ltd. All other authors report no competing interests. Un article de Wikipdia, l'encyclopdie libre. Et surtout dans la semaine conscutive linfection, il est observ chez ces patients une chute des lymphocytes T, avec une lymphopnie en forme de V. Toutes les situations de stress aigu peuvent se compliquer de lymphopnie via laugmentation des taux circulants de cortisol par le systme endocrinien et spcifiquement par les glandes corticosurrnales. Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, et al. Except in earthquakes, explosions, building collapses, and some types of terrorist attacks, the same holds true for large-scale disasters. Pathway and gene set enrichment analysis were performed using the ConsensusPathDB-human enrichment software (http://cpdb.molgen.mpg.de/) (Kamburov etal., 2011). We further identified a signal associated with total hip replacement with opposite direction of effects between men and women, rs10282983 (Psex-diff= 4.93 1016, Phet-diff= 7.66 1014; female OR= 1.15, 95% CI= 1.111.19, P-female= 2.21 1014; male OR= 0.92, 95% CI= 0.880.96, P-male= 5.16 104). Stoneman Syndrome. Self-reported cases of total hip replacement from the NHS and NHS2 were analyzed for the GO meta-analysis. Nikolas Cruz sentencing latest: Prosecution rests rebuttal case We examined the druggability status of all 637 genes with at least one piece of supporting evidence from fine-mapping and functional analyses (Table S10; STAR Methods). This work was partly funded by the National Nature Science Foundation of China Key Project (T.L., 81630030 and 81920108018); National Nature Science Foundation of China Project (C.Z., 82001413); Project for Hangzhou Medical Disciplines of Excellence & Key Project for Hangzhou Medical Disciplines (T.L., 202004A11); Introduction Project of Suzhou Clinical Expert Team (X.D. Yang J, Wray NR, Visscher PM (2010), Comparing Apples and Oranges: Equating the Power of Case-Control and Quantitative Trait Association Studies. Limma-voom (Law etal., 2014) was used to remove heteroscedasticity from the estimated expression data. (2020), Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data. (2014), Genetics of rheumatoid arthritis contributes to biology and drug discovery. Twitter. American Journal of Human Genetics 108:1488-1501. BioRxiv a publi le premier preprint sur SARS-CoV-2 (alors nomm 2019-nCoV) le 19 janvier 2020[183] et medRxiv le 24 janvier[184]. Et malheureusement, les trois derniers sont entrs dans notre vie avec les craintes lies une pidmie, une pandmie ou la mort[9]. The site is secure. Given that COVID-19 and SARS have similar clinical features [7], SARS-CoV-2 may have a similar pathogenesis mechanism as SARS-CoV. Each lumbar intervertebral disc was rated for disc bulging and Schneidermann score. Conversion of MRI for OA diagnosis: Conversion of MRI for OA diagnosis was dependent on two MRI ratings: disc bulging and Schneiderman score. A study indicated the mean incubation period was 5.2 days (95% confidence interval [95%CI]: 4.17.0) [13]. The .gov means its official. Wishart D.S., Feunang Y.D., Guo A.C., Lo E.J., Marcu A., Grant J.R., Sajed T., Johnson D., Li C., Sayeeda Z. DrugBank 5.0: a major update to the DrugBank database for 2018. Second, assay technical artifacts and differences in data analysis may impact the results significantly. If you've seen someone with an invisible name and display picture in Discord and thought it was cool, you're in luck, because this is an up-to-date (2018) guide on how to make your Discord display name and avatar invisible! We performed an investigation for all genes within 1Mb (upstream and downstream) of the 100 SNVs in preserved and lesioned cartilage and subchondral bone samples from the same donor were obtained from the Research in Articular osteoArthritis Cartilage (RAAK) study consisting of patients with osteoarthritis who underwent joint replacement surgery due to an end-stage disease (Coutinho de Almeida etal., 2019; den Hollander etal., 2019; Ramos etal., 2014). A Horse And Two Goats Icse Notes, Less common symptoms include headache, dizziness, abdominal pain, diarrhoea, nausea, and vomiting [7], [30]. Murad NAA, Cullen JK, McKenzie M, Ryan MT, Thorburn D, Gueven N, Kobayashi J, Birrell G, et al. Genome Medicine 8:84. Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. The SLC1A1 agonist and neuropathic pain inhibitor pregabalin is commonly prescribed in osteoarthritis. Png can be used personally or non-commercially and chill members, daily gifs & icons etc White 2! White discord 2 png and white discord 2 transparent for download. En revanche il est suggr qu'il n'existe pas d'immunit croise pour les lymphocytes B qui produisent des anticorps[131]. Emerging roles of TRIO and F-actin-binding protein in human diseases. Details for the cohort-specific raw genetic/genomic data are listed in the key resources table. Deficiency of the HCAR2 agonist niacin (vitamin B3) was associated with knee osteoarthritis progression in the Japanese ROAD cohort (Muraki etal., 2014). Rare diseases are those that affect only a small percentage of the worlds population, with scientists struggling to find causes and cures. (2022), Whole genome sequencing reveals host factors underlying critical Covid-19. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. Black Desert Sudamerica image for free from this website Icon Gratuit 3D Icon! For additional information on the 100 identified osteoarthritis associated SNVs, we examined their association in several osteoarthritis endophenotype and structural phenotype GWAS studies. Disasters Abundance values were normalized by the sum of all protein abundances in a given sample, then log2-transformed and quantile normalized. Wray NR, Yang J, Goddard ME, Visscher PM (2010), The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling. Mais ces deux variants contiennent surtout des mutations comme E484K qui affaiblissent lefficacit des anticorps des vaccins de premire gnration et facilitent les rinfections au SARS-CoV-2[153]. The array signal intensities were analyzed by the Agilent GeneSpring GX software (version 11.5; Agilent Technologies). Osteoarthritis can affect every synovial joint and an increase in body mass index (BMI) is associated with risk of disease (Geusens and van den Bergh, 2016). The members of the ARGO-Larissa Consortium are Konstantinos Malizos, Lydia Anastasopoulou, Aspasia Tsezou, Eleni Zengini, J. Les sites de rplication secondaires du SARS-CoV-1 dans les formes svres sont le cur, les glandes sudoripares de la peau, les reins et le systme endocrinien qui rgule les hormones (glandes surrnales, la parathyrode et lhypophyse)[88],[89]. #discord logo png black #discord icon png black E-Mail. Black Discord Icon #165135. Hong Kong Degenerative Disc Disease Population Cohort (HKDDDPC) is a a population-based cohort with subjects openly recruited via newspapers advertisement, posters and e-mails, regardless of their social and economic status (Li etal., 2016). We found 11,897 genome-wide significantly associated single nucleotide variants (SNVs) using a threshold of p< 1.3 108, to account for the effective number of independent tests. NOS3 is associated with sporadic limb defects in mice (Gregg etal., 1998) and has been implicated in bone remodeling in rats (Hukkanen etal., 1999). Detailed information about the study subjects, diagnosis, genotyping, quality control, and statistical analyses was provided in the original papers [14]. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. We excluded variants with poor imputation quality (R2< 0.3), if the effective sample size was< 20 and if the minor allele count was< 6. The data generated in this study will be available from the corresponding author on reasonable request. Enrichment was calculated using all osteoarthritis associated lead SNVs and the fine-mapped variants, per osteoarthritis phenotype and all together. SNPs with differing alleles, SNPs with > 0.2 allele frequency difference, SNPs not in HRC reference panel were also removed. The P value thresholds ranging from 1.3x108 to 1.0x104 with LD clumping parameters of R2= 0.1 over 1Mb windows and 10,000 permutations to account for the overfitting. 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