government site. Environmental tobacco smoke exposure and perinatal outcomes: A systematic review and meta-analyses, Acta Obstetricia et Gynecologica Scandinavica. An OR is a ratio of the odds of having a condition in the exposed to the odds of the condition in the unexposed and can be adjusted for significant covariates or unadjusted. One study used tissues from elective first trimester (612 weeks) abortions to examine DNA methylation in samples of placenta and liver (Fa et al., 2018). Affected genes included those known to be related to nicotine dependence, smoking cessation, and placental and embryonic development. Theory and method, The epidemiology of smoking during pregnancy: Smoking prevalence, maternal characteristics, and pregnancy outcomes, Health effects of passive smoking10: Summary of effects of parental smoking on the respiratory health of children and implications for research, Developmental consequences of prenatal tobacco exposure, Prenatal tobacco effects on neuropsychological outcomes among preadolescents, Journal of Developmental and Behavioral Pediatrics, Exposure to cigarette smoke disrupts CCL20-mediated antimicrobial activity in respiratory epithelial cells, Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: A population-based study in Sweden, A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement, The role of the children of twins design in elucidating causal relations between parent characteristics and child outcomes, Journal of Child Psychology and Psychiatry, Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds, Prenatal undernutrition and cognitive function in late adulthood, Proceedings of the National Academy of Sciences, Early life insult from cigarette smoke may be predictive of chronic diseases later in life, Beginning to understand microRNA function, Smoking in pregnancy and lactation: A review of risks and cessation strategies, European Journal of Clinical Pharmacology, Behavioral and neural consequences of prenatal exposure to nicotine, Journal of the American Academy of Child & Adolescent Psychiatry, Maternal smoking during pregnancy and psychiatric adjustment in late adolescence, Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta, 60- and 72-month follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol: Cognitive and language assessment, A follow-up study of attentional behavior in 6-year-old children exposed prenatally to marihuana, cigarettes, and alcohol, DNA methylation profiles of the brain-derived neurotrophic factor (, Developmental origins of health and disease. Hjja, Hajnalka Bethesda, MD 20894, Web Policies DNA methylation and imprinting: Why bother? Blake KV, Gurrin LC, Evans SF, Beilin LJ, Landau LI, Stanley FJ, & Newnham JP (2000). Multiple reviews of the epidemiological evidence have been published over the past four decades as evidence has grown stronger and the adverse outcomes attributed to maternal smoking and secondhand smoke exposure have expanded.This review presents findings demonstrating latent and persistent metabolic effects in offspring of smoking mothers similar to those observed in studies of maternal undernutrition during pregnancy. Birth Defects Research. The miRNAs, previously implicated in growth and development, were miR-16, miR-21, miR-146a, and miR-182. Abe, Yukiko Yuan, H.R. Tobacco smoke contains thousands of known toxic components including known human carcinogens in addition to nicotine and carbon monoxide. Neiderhiser, Jenae M. Hirose, Nobuyoshi Would you like email updates of new search results? CpGs are grouped by gene, and all 26 CpGs affected in the MoBa cohort were changed in the same direction and similar magnitude in the NEST replicate. and NCHS Data Brief. (2006). An interesting finding was a reduced risk of hypospadias and skin defects in offspring of smoking mothers. Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? } There is now an abundant epidemiological, clinical, and animal research literature in support of the DOHaD theory. Estimates of effect of maternal smoking during pregnancy on BMI z-scores for boys (above) and girls (below) compared with no smoking during pregnancy (horizontal line at zero). Has data issue: true Joubert BR, Hberg SE, Bell DA, Nilsen RM, Vollset SE, Midttun O, London SJ (2014). Martelli, A.
Also reviewed here are the effects of maternal smoking on the epigenome of the child at birth and in later life. Rig jr., Jnos Effects on cognitive functioning at age three, A clinical trial of change in maternal smoking and its effect on birth weight, Journal of the American Medical Association, Experimental and quasi-experimental designs for generalized causal inference, A systematic review and meta-analysis of prospective studies on the association between maternal cigarette smoking and preterm delivery, American Journal of Obstetrics and Gynecology, Gene expression patterns in human placenta, Famine, third-trimester pregnancy weight gain, and intrauterine growth: The Dutch Famine Birth Cohort Study, In utero tobacco exposure epigenetically modifies placental, Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression, Developmental origins of health and disease: Environmental exposures, Genomic DNA methylation among women in a multiethnic New York City birth cohort, Cancer Epidemiology, Biomarkers, and Prevention, Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring, Do intrauterine or genetic influences explain the foetal origins of chronic disease? Maternal smoking during pregnancy and childhood overweight and fat distribution: The KOALA birth cohort study, U.S. Department of Health and Human Services. Oken, Levitan, and Gillman (2008) conducted a metaanalysis of observational studies of maternal cigarette smoking during pregnancy and child overweight (BMI 85th percentile or BMI 90th percentile for age and sex). 1.
Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A In a study of newborns, of 456 mothers of infants tested, 79.6% had no smoke exposure, 13.8% were exposed to secondhand smoke and 6.6% smoked during pregnancy (Geerts et al., 2007). Ploeg, Mirjam Gene expression analysis (RNA-seq) in mothers and children identified pathways preferentially affected by smoking, including the WNT signaling pathway in both mothers and children. and Advancement in bioinformatic and biostatistics approaches is key to develop a comprehensive analysis of these biological systems. Modified from Riedel, Fenske, et al., 2014, EHP 122:761767, Similar CpG methylation changes in relation to maternal smoking status in the Norwegian mother and child cohort study (MoBa) and the newborn epigenetics study (NEST) replication study. Estimates of effect of maternal smoking during pregnancy on BMI z-scores for boys, Similar CpG methylation changes in relation to maternal smoking status in the Norwegian, MeSH An ever-increasing amount of evidence suggests that such regulatory processes may play a pivotal role both in the initiation of pregnancy and in the later processes of embryonic and fetal development, thus determining long-term effects even . Mattsson K1, Jnsson I, Malmqvist E, Larsson HE, & Rylander L (2015). Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Suter and colleagues found placental hypomethylation of the promoter for CYP1A1, a gene known to be upregulated in smokers (Suter et al., 2010) and went on to assess correlative changes in placental DNA methylation and gene expression using the 27 K BeadChip array (Suter et al., 2011). This article is a U.S. Government work and is in the public domain in the USA. Careers, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina. Lester, Barry United States Environmental Protection Agency, email: Lucia, Alejandro Differences in BMI zscores between offspring of smoking and nonsmoking mothers: A longitudinal study of German children from birth through 14 years of age. A Report of the Surgeon General. Hostname: page-component-5d6d958fb5-27v8q Epigenetic alterations, such as DNA methylation (DNAm), miRNAs expression, and histone modifications, belong to possible underlying mechanisms linking maternal tobacco smoking during pregnancy and adverse birth outcomes and later child's development. CONFLICT OF INTEREST The author has no conflict of interest in publishing this work. However, there are still huge gaps to fill in, including on the impact on miRNA expression and histone modifications to get a better view of the whole epigenetic machinery. In early pregnancy, epigenetic changes using cell free DNA (cfDNA) are largely unexplored. Prevalence of maternal smoking ranged from 5.5 to 38.7%, prevalence of overweight ranged from 6.3 to 32.1%, and prevalence of obesity ranged from 2.6 to 17%. Render date: 2022-11-20T23:47:26.986Z Parental smoking and childhood obesity: Higher effect estimates for maternal smoking in pregnancy compared with paternal smoking--a meta-analysis, Tobacco and pregnancy: Overview of exposures and effects. Outcomes were cord blood insulin, proinsulin, IGF-I, IGF-II, leptin, adiponectin, glucose-to-insulin ratio, and proinsulin-to-insulin ratio. Miyachi, Motohiko body mass index, smoking status, socioeconomic status, gravidity, parity, gestational age at birth .
Maternal smoking during pregnancy leaves its lasting - ScienceDaily Jaddoe et al. 2021;325:265279. PMC legacy view Federal government websites often end in .gov or .mil. (2016) found adjusted odds ratios (OR) for any versus no maternal SHS exposure and isolated birth defects that were significantly higher for neural tube defects, orofacial clefts, bilateral renal agenesis, amniotic band syndrome and atrial septal defects. Changes in this pathway had the highest significance in children. Guerrero-Preston R, Goldman LR, Brebi-Mieville P, Ili-Gangas C, Lebron C, Witter FR, Sidransky D (2010). Smoking during pregnancy is a well-known risk factor for many health problems in children, including low birth weight, heart defects and asthma. 2022 Sep 7;23(18):10293. doi: 10.3390/ijms231810293. Careers. Disclaimer, National Library of Medicine Cosin-Tomas M, Cilleros-Portet A, Aguilar-Lacasaa S, Fernandez-Jimenez N, Bustamante M. Curr Environ Health Rep. 2022 Sep;9(3):502-512. doi: 10.1007/s40572-022-00361-9. U.S. Department of Health and Human Services. Parental smoking during pregnancy and risk of overweight and obesity in the daughter. 2022 May;52(3):511-525. government site. Marceau, Kristine Total loading time: 0.554 WHO Global Report on Trends in Prevalence of Tobacco Smoking 20002025. Maternal smoking causes lower birth weight, birth defects, and other adverse pregnancy outcomes. official website and that any information you provide is encrypted Sharp, H M "displayNetworkMapGraph": false, The extent to which the DNA methylome is altered by maternal smoking remains to be fully elucidated, as the number of significantly altered CpGs has increased with the advancing technology used and the CpG coverage of the various approaches, from the 27 K BeadChip to the 450 K BeadChip to WGBS. A workshop (Behl et al., 2013) reviewed 18 studies on maternal exposure to smoking during pregnancy and offspring type 1 diabetes (T1D) and found that those studies did not support an association between maternal or paternal smoking during pregnancy and offspring T1D. An official website of the United States government. These findings were attributed to variations in fetal nutrient delivery during a period of developmental plasticity in which the fetus responds to its environment with adaptive changes in organ structure and metabolism, and this idea became known as the Barker Hypothesis. Offspring of smoking mothers were at increased risk of overweight compared to offspring of nonsmoking mothers, with a pooled adjusted OR of 1.50 (95% CI 1.36, 1.65). The statistical power afforded by the large number of samples in this meta-analysis allowed detection of statistically significant differential methylation of over 6,000 CpGs, about half of which corresponded to 2,017 genes not previously identified as differentially methylated by smoking. Associations between maternal periconceptional exposure to secondhand tobacco smoke and major birth defects, American Journal of Obstetrics and Gynecology. Studies have also reported increased risk of insulin resistance, type 2 diabetes, and hypertension in offspring of smoking mothers, although the evidence here is weaker than for overweight/obesity. In contrast with miRNA and histone modifications, DNAm has been the most extensively studied epigenetic mechanism with regard to in utero exposure to maternal tobacco smoking. A novel experimental method for disentangling effects, Prenatal smoking might not cause attention-deficit/hyperactivity disorder: Evidence from a novel design, Tobacco smoke: unraveling a controversial subject, Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring, American Journal of Medical Genetics. The Impact of the Main Negative Socio-Economic Factors on Female Fertility. Herberth G, Daegelmann C, Weber A, Rder S, Giese T, Krmer U, LISAplus Study Group. Hoyt AT, Canfield MA, Romitti PA, Botto LD, Anderka MT, Krikov SV, Feldkamp ML (2016). Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease. Tiesler, Carla M. T. These placental epigenetic alterations are likely to program fetal development in the prenatal period for long-term neurodevelopmental outcomes (Nugent & Bale, 2015). (2014) examined the timing of maternal smoke exposure as well as fathers smoking before conception and maternal grandmothers smoking during pregnancy. Golding J, Gregory S, Northstone K, Iles-Caven Y, Ellis G, & Pembrey M (2019). Pregnancy and early life are believed to be periods when environmental impacts on the epigenome can have long-lasting implications on health. This article seeks to explore many of the previously described epigenetic alterations associated with maternal cigarette smoking during pregnancy and assess how such changes may have consequences for both fetal growth and development, as well as later child health, behavior, and well-being. Silva-Jose C, Snchez-Poln M, Barakat R, Gil-Ares J, Refoyo I. J Clin Med. Components of the metabolic syndrome include abdominal obesity, dyslipidemia, hypertension, and insulin resistance, and these conditions increase risk of heart disease, type 2 diabetes, and stroke. Higgins, Rosemary As the field of research comprising long-term effects of the developmental environment evolved, it became known as the DOHaD theory. Epigenetic processes are emerging as key mechanisms through which the influence of developmental exposures is "remembered" with consequences on foetal development that persist into later life. (2013), presumably due to secondhand smoke exposure of the mother. PMC
Understanding How Physical Activity During Pregnancy Impacts the Berk, Michael Swiergiel, Artur H. 2013. According to the classical definition of transgenerational epigenetic inheritance, environmental triggers that hit pregnant female individuals (F0) can affect "directly" not only the first new generation (F1), but also its germ cells that represent the second generation (F2). However, it should be mentioned that the reviewers also listed two studies of childhood secondhand smoke exposure that both found a positive relationship with T1D (Hathout, Beeson, Ischander, Rao, & Mace, 2006; Skrodeniene et al., 2008). The relationship between maternal plasma cotinine (nicotine metabolite and biomarker of smoking) during pregnancy and CpG methylation was investigated using the 450 K BeadChip array for 1,062 cord blood samples from the Norwegian Mother and Child Cohort Study (MoBa) (Joubert et al., 2012). JAMA. and Here, we hypothesized that there are long-term and persistent epigenetic effects following maternal smoking during pregnancy on adolescent offspring DNA methylation, independent of paternal and postnatal smoke exposure. Clipboard, Search History, and several other advanced features are temporarily unavailable. Significance levels for transitions were stronger near smoking-related DMRs, indicating that chromatin dynamics were linked to differential methylation associated with maternal smoking. About 58 million nonsmokers in the United States are exposed to second-hand smoke (SHS, smoke exhaled by smokers or from burning tobacco products) (CDC, https://www.cdc.gov/vitalsigns/tobacco/). Int J Mol Sci. The authors declare no conflict of interest. Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood. A study of 344 cases of T1D and three times as many controls matched for HLA haplotype and birth year among children born between 1999 and 2005 in a Swedish county found that maternal smoking during pregnancy was associated with higher risk of offspring T1D, OR 2.83, 95% CI 1.674.80 for 19 cigarettes per day and OR 3.91, 95% CI 1.2212.51 for >9 cigarettes per day (Mattsson, Jnsson, Malmqvist, Larsson, & Rylander, 2015). All views expressed in this article are those of the author and do not represent views or policies of the U.S. Environmental Protection Agency, which wholly funded this work. Effects of methylation in these different contexts vary and are not well understood, although increased CpG methylation in promotors is generally associated with decreased gene expression. 2013. (2013) of maternal smoking and offspring type 2 diabetes (T2D), insulin resistance, hyperglycemia or metabolic syndrome found 12 studies and determined that it was not possible to reach a clear conclusion because of the diversity of endpoints assessed among these studies. Using the 450 K BeadChip array in an epigenome-wide association study, Kpers et al. Pediatrics. 2014 Oct;122(10):1147-53. doi: 10.1289/ehp.1307892. Epidemiological evidence over the past four decades has grown stronger and the adverse outcomes attributed to maternal smoking and secondhand smoke exposure have expanded. ( 2013 ), presumably due to secondhand tobacco smoke and major birth defects, and ratio! Adiponectin, glucose-to-insulin ratio, and other adverse pregnancy outcomes higgins, Rosemary as the DOHaD theory those known be... 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